Construction of antimicrobial and biocompatible cotton textile based on quaternary ammonium salt from rosin acid

编号 020024605

推送时间 20200706

研究领域 林产化工 

年份 2020 

类型 期刊 

语种 英语

标题 Construction of antimicrobial and biocompatible cotton textile based on quaternary ammonium salt from rosin acid

来源期刊 International Journal of Biological Macromolecules

期 第246期

发表时间 20200130

关键词 Cotton textile;  Quaternary ammonium salt;  Rosin acid;  Antimicrobial;  Antibiofilm;  Biocompatibility; 

摘要 Antimicrobial cotton textiles (CT) show great promise for wound dressings. However, modifying CTs to have antimicrobial properties requires balancing the killing of microbes while protecting normal cells. In this study, the surface of CT was modified using maleopimaric acid quaternary ammonium cations (MPA-N+) from rosin acid. The surfaces morphology and chemical composition were determined by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), which confirmed that the MPA-N+ modified CT (CT-g-MPA-N+) was prepared. CT-g-MPA-N+ shows strong and broad spectrum antimicrobial activities against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus). It also exhibits prominent durability of antimicrobial capability even after soaking in PBS for 6 days, and can effectively inhibit bacterial biofilm formation. Most importantly, the excellent biocompatibility of CT-g-MPA-N+ was verified by hemocompatible and cytotoxic assays. This work is believed to be promising method to prepare antimicrobial cotton textiles by surface modification and suggest the great potential application in wound dressing.

服务人员 尚玮姣

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