Dual-functional antimicrobial coating based on the combination of zwitterionic and quaternary ammonium cation from rosin acid

编号 020032803

推送时间 20220131

研究领域 林产化工 

年份 2022 

类型 期刊 

语种 英语

标题 Dual-functional antimicrobial coating based on the combination of zwitterionic and quaternary ammonium cation from rosin acid

来源期刊 Composites Part B: Engineering

期 第328期

发表时间 20220108

关键词 Antimicrobial;  Antibiofilm;  Coating;  Dopamine;  Zwitterionic;  Maleopimaric acid quaternary ammonium cation; 

摘要 Treatment of implant-associated infection is becoming more challenging, especially when?bacterial biofilms?form on the surface of implants. To address the challenge of biofilm infection, developing dual-functional antimicrobial coatings (antimicrobial and antifouling) to combat?bacterial biofilm?infection are superior to those based on a single modality due to avoiding the adverse effects arising from the latter. In this work, we reported an effective dual-functional coating based on the use of synthetic terpolymers, which combined dopamine, zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) and maleopimaric acid?quaternary ammonium?cation (MPA-N+). The modified surfaces were characterized by scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), X-ray spectroscopy (XPS) and water?contact angle measurements. The bactericidal efficacies of dual-functional coating were demonstrated by 1.00, 1.09 and 0.94 log reduction of Gram-positive?Staphylococcus aureus?and Gram-negative?Escherichia coli,?Pseudomonas?aeruginosa, respectively, and effectively inhibited pathogenic?biofilm formation. Moreover, the dual-function coating reduced protein and platelet absorption, while showing minimal cytotoxicity to the mammalian cells. Notably, an?in vivo?implantation model showed that the dual-functional coating eradicated the pathogenic biofilm from the implants, preventing host tissue damage and inflammation. Taken together, this dual-functional coating displayed great therapeutic potential in treating the formidable clinic problems caused by pathogenic biofilm and the accompanying inflammation.

服务人员 尚玮姣

服务院士 宋湛谦

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