BRASSINOSTEROID-INSENSITIVE2 Negatively Regulates the Stability of Transcription Factor ICE1 in Response to Cold Stress in Arabidopsis

编号 040020203

推送时间 20190902

研究领域 森林培育 

年份 2019 

类型 期刊 

语种 英语

标题 BRASSINOSTEROID-INSENSITIVE2 Negatively Regulates the Stability of Transcription Factor ICE1 in Response to Cold Stress in Arabidopsis

来源期刊 Plant Cell

期 第202期

发表时间 20190813

关键词 BIN2;  INDUCER OF CBF EXPRESSION1;  negatively regulate;  freezing tolerance;  cold stress; 

摘要 Cold acclimation is a crucial strategy for plant survival at freezing temperatures. CBF (C-REPEAT BINDING FACTOR) genes are rapidly and transiently induced by low temperature and play important roles in cold acclimation. However, the mechanism underlying the attenuation of CBF expression during the later stages of the cold stress response is obscure. Here, we show that the protein kinase BIN2 (BRASSINOSTEROID-INSENSITIVE2) interacts with and phosphorylates ICE1 (INDUCER OF CBF EXPRESSION1) in Arabidopsis under prolonged cold stress, facilitating the interaction between ICE1 and HOS1 and thereby promoting ICE1 degradation. The kinase activity of BIN2 is inhibited during the early stages of the cold stress response and is subsequently restored, suggesting that BIN2 mainly downregulates ICE1 abundance when CBF expression is attenuated. A loss-of-function mutant of ICE1 partially suppresses the cold-induced expression of CBFs and compromises the enhanced freezing tolerance of bin2-3 bil1 bil2. These findings reveal an important role for BIN2 in fine-tuning CBF expression, and thus in balancing plant growth and cold acclimation.

服务人员 孙小满

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