Elucidating the biology of transcription factor–DNA interaction for accurate identification of cis-regulatory elements

编号 040036003

推送时间 20220912

研究领域 森林培育 

年份 2022 

类型 期刊 

语种 英语

标题 Elucidating the biology of transcription factor–DNA interaction for accurate identification of cis-regulatory elements

来源期刊 Current Opinion in
Plant Biology

期 第360期

发表时间 20220801

关键词 Cis-regulatory elements;  Gene regulation;  Transcription factor-DNA interaction;  Transcription factors;  Transcriptional regulation; 

摘要 Transcription factors (TFs) play a critical role in determining cell fate decisions by integrating developmental and environmental signals through binding to specific cis-regulatory modules and regulating spatio-temporal specificity of gene expression patterns. Precise identification of functional TF binding sites in time and space not only will revolutionize our understanding of regulatory networks governing cell fate decisions but is also instrumental to uncover how genetic variations cause morphological diversity or disease. In this review, we discuss recent advances in mapping TF binding sites and characterizing the various parameters underlying the complexity of binding site recognition by TFs.

服务人员 孙小满

服务院士 尹伟伦

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