Three-Component Dynamic Covalent Chemistry: From Janus Small Molecules to Functional Polymers

编号 020035705

推送时间 20220822

研究领域 林产化工 

年份 2022 

类型 期刊 

语种 英语

标题 Three-Component Dynamic Covalent Chemistry: From Janus Small Molecules to Functional Polymers

来源期刊 Journal of the American Chemical Society?

期 第357期

发表时间 20211206

关键词 MULTICOMPONENT REACTIONS;  WEIGHT DISTRIBUTION;  POLYMERIZATION;  ACID;  DRUG;  BOND; 

摘要 A new mtilticoinponent reaction involving 2-hydroxybenzaldehyde, amine, and 2-mercaptobenzaldehyde (HAM reaction) has been developed and applied to multi-component polymerization and controlled radical polymerization for the construction of random and block copolymers. This chemistry features mild reaction conditions, high yield, simple isolation and water as the only by product. With the advantages of the distinct nucleophilicity of thiol and hydroxyl groups, the chemistry could be used for stepwise labeling and modifications on primary amines. The Janus chemical joint formed from this reaction exhibits degradability in buffers and generates the corresponding starting reagents, allowing amine release. Interestingly, the chemical joint exhibits thermally activated reversibility with water as the catalyst. This multicomponent dynamic covalent feature has been applied to the metamorphosis of random and block copolymers, generating polymers with diverse architectures. This chemistry is expected to be broadly applicable to synthetic Polymer chemistry and materials science.

服务人员 尚玮姣

服务院士 宋湛谦

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