An injectable self-healing hydrogel-cellulose nanocrystals conjugate with excellent mechanical strength and good biocompatibility

编号 020023505

推送时间 20200420

研究领域 林产化工 

年份 2020 

类型 期刊 

语种 英语

标题 An injectable self-healing hydrogel-cellulose nanocrystals conjugate with excellent mechanical strength and good biocompatibility

来源期刊 Carbohydrate Polymers

期 第235期

发表时间 20190715

关键词 Cellulose nanocrystals (CNCs);  Graft;  Nanocomposite hydrogel;  Reversible covalent bond;  Self-healing; 

摘要 In this work, a novel strategy for the construction of injectable self-healing nanocomposite (NC) hydrogels dominated by reversible boronic ester bonds was demonstrated. Specifically, NC hydrogels were constructed by the solution-mixing of N,N-dimethylacrylamide-stat-3-acrylamidophenylboronicacid statistical copolymers (PDMA-stat-PAPBA) and poly(glycerolmonomethacrylate) (PGMA) chains grafted cellulose nanocrystals (CNC-g-PGMA). Rheology analysis indicated the as-constructed NC hydrogel displayed about 7-fold increase in the storage modulus with a low CNCs loading level of 1.43?wt% in comparison with PGMA/PDMA-stat-PAPBA hydrogel without CNCs. Furthermore, the mechanical strength of the CNC-g-PGMA/PDMA-stat-PAPBA hydrogel was far superior to that of its PGMA/PDMA-stat-PAPBA/CNCs hydrogel counterpart, in which PGMA chains were not covalently grafted on the surfaces of CNCs. Due to reversible boronic ester bonds cross-linking networks, CNC-g-PGMA/PDMA-stat-PAPBA NC hydrogel exhibited excellent self-healing and injectable properties as well as pH/glucose responsive sol-gel transitions. Good biocompatibility was also demonstrated through in vitro cytotoxicity tests.

服务人员 尚玮姣

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