Epitranscriptomic mRNA modifications governing plant stress responses: underlying mechanism and potential application

编号 040036604

推送时间 20221024

研究领域 森林培育 

年份 2022 

类型 期刊 

语种 英语

标题 Epitranscriptomic mRNA modifications governing plant stress responses: underlying mechanism and potential application

来源期刊 Plant Biotechnology Journal

期 第366期

发表时间 20220824

关键词 mRNA modi?cation;  m6A;  stress response;  epitranscriptomics; 
crop breeding; 

摘要 Plants inevitably encounter environmental adversities, including abiotic and biotic stresses, which significantly impede plant growth and reduce crop yield. Thus, fine-tuning the fate and function of stress-responsive RNAs is indispensable for plant survival under such adverse conditions. Recently, post-transcriptional RNA modifications have been studied as a potent route to regulate plant gene expression under stress. Among over 160 mRNA modifications identified to date, N6-methyladenosine (m6A) in mRNAs is notable because of its multifaceted roles in plant development and stress response. Recent transcriptome-wide mapping has revealed the distribution and patterns of m6A in diverse stress-responsive mRNAs in plants, building a foundation for elucidating the molecular link between m6A and stress response. Moreover, the identification and characterization of m6A writers, readers and erasers in Arabidopsis and other model crops have offered insights into the biological roles of m6A in plant abiotic stress responses. Here, we review the recent progress of research on mRNA modifications, particularly m6A, and their dynamics, distribution, regulation and biological functions in plant stress responses. Further, we posit potential strategies for breeding stress-tolerant crops by engineering mRNA modifications and propose the future direction of research on RNA modifications to gain a much deeper understanding of plant stress biology.

服务人员 孙小满

服务院士 尹伟伦

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