UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis

编号 040028203

推送时间 20210315

研究领域 森林培育 

年份 2021 

类型 期刊 

语种 英语

标题 UVR8 interacts with de novo DNA methyltransferase and suppresses DNA methylation in Arabidopsis

来源期刊 Nature Plants

期 第282期

发表时间 20210125

关键词 DNA methylation;  Light responses;  Plant signalling; 

摘要 DNA methylation is an important epigenetic gene regulatory mechanism conserved in eukaryotes. Emerging evidence shows DNA methylation alterations in response to environmental cues. However, the mechanism of how cells sense these signals and reprogramme the methylation landscape is poorly understood. Here, we uncovered a connection between ultraviolet B (UVB) signalling and DNA methylation involving UVB photoreceptor (UV RESISTANCE LOCUS 8 (UVR8)) and a de novo DNA methyltransferase (DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2)) in Arabidopsis. We demonstrated that UVB acts through UVR8 to inhibit DRM2-mediated DNA methylation and transcriptional de-repression. Interestingly, DNA transposons with high DNA methylation are more sensitive to UVB irradiation. Mechanistically, UVR8 interacts with and negatively regulates DRM2 by preventing its chromatin association and inhibiting the methyltransferase activity. Collectively, this study identifies UVB as a potent inhibitor of DNA methylation and provides mechanistic insights into how signalling transduction cascades intertwine with chromatin to guide genome functions.

服务人员 孙小满

服务院士 尹伟伦

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