Seasonal plasticity and diel stability of H3K27me3 in natural fluctuating environments

编号 040025905

推送时间 20201005

研究领域 森林培育 

年份 2020 

类型 期刊 

语种 英语

标题 Seasonal plasticity and diel stability of H3K27me3 in natural fluctuating environments

来源期刊 Nature Plants

期 第259期

发表时间 20200831

关键词 H3K27me3;  diel stability;  environmental
changes;  seasonal plasticity; 

摘要 Diel and seasonal oscillations are two major environmental changes in nature. While organisms cope with the former by the well-characterized mechanism of the circadian clock1,2, there is limited information on the molecular mechanisms underlying long-term responses to the latter3,4,5. Histone H3 lysine 27 trimethylation (H3K27me3), a repressive histone modification, imparts stability and plasticity to gene regulation during developmental transitions6,7,8,9. Here we studied the seasonal and diel dynamics of H3K27me3 at the genome-wide level in a natural population of perennial Arabidopsis halleri and compared these dynamics with those of histone H3 lysine 4 trimethylation (H3K4me3), an active histone modification. Chromatin immunoprecipitation sequencing revealed that H3K27me3 exhibits seasonal plasticity and diel stability. Furthermore, we found that the seasonal H3K27me3 oscillation is delayed in phase relative to the H3K4me3 oscillation, particularly for genes associated with environmental memory. Our findings suggest that H3K27me3 monitors past transcriptional activity to create long-term gene expression trends during organismal responses over weeks in natural fluctuating environments.

服务人员 孙小满

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