Stimuli-responsive hydrogels as a model of the dynamic cellular microenvironment

编号 020025904

推送时间 20201005

研究领域 林产化工 

年份 2020 

类型 期刊 

语种 英语

标题 Stimuli-responsive hydrogels as a model of the dynamic cellular microenvironment

来源期刊 Polymer Journal

期 第259期

发表时间 20200514

关键词 PLURONIC F-127 GELS;  HYALURONIC-ACID;  SUPRAMOLECULAR HYDROGEL;  CONTROLLED-RELEASE;  BLOCK-COPOLYMERS;  MATRIX STIFFNESS;  GROWTH-FACTOR;  PH;  POLYMER;  DEGRADATION; 

摘要 Stimulus-responsive hydrogels are highly attractive as the surrogate materials that can simulate dynamic mechanical microenvironments surrounding biological cells in vivo. This review tries to provide with comprehensive overviews on the previous achievements, present pitfalls and challenges, and future perspectives on the recent development on stimulus-responsive hydrogel materials for the dynamic control of cell behaviors.Ample evidence has demonstrated that biological cells not only react to biochemical cues from the surrounding microenvironments but also sensitively detect the mechanical properties of the extracellular matrix and neighboring cells to adapt their shape, function, and fate. Mechanical aspects in biology, called mechanobiology, have been attracting biologists, chemists, physicists, and mechanical engineers. However, most in vitro studies to date have heavily relied on covalently cross-linked hydrogels with prefixed and hence unchangeable mechanical properties, although the mechanical properties of the cellular microenvironment are never uniform or static. From this context, stimuli-responsive hydrogels are highly attractive as surrogate materials that can simulate dynamic physical microenvironments in vivo. This review tries to provide a comprehensive overview of previous achievements, present pitfalls and challenges, and future perspectives on the recent development of stimuli-responsive hydrogel materials for the dynamic control of cell behavior.

服务人员 尚玮姣

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