Antifungal Activity of beta-Pinene-Based Hydronopyl Quaternary Ammonium Salts Against Phytopathogenic Fungi

编号 020031001

推送时间 20210927

研究领域 林产化工 

年份 2021 

类型 期刊 

语种 英语

标题 Antifungal Activity of beta-Pinene-Based Hydronopyl Quaternary Ammonium Salts Against Phytopathogenic Fungi

来源期刊 Natural Product Research

期 第310期

发表时间 20200821

关键词 hydronopyl;  quaternary ammonium salt;  synthesis;  antifungal activity; 

摘要 beta-Pinene can be used as a cheap source to synthesize a large number of high value-added derivatives. In this study, a series of beta-pinene derivatives was prepared, and the antifungal activities of the compounds were assessed against phytopathogenic fungi. Eight N-alkyl hydronopyl diethyl ammonium halide salts were synthesized by the reaction of hydronopyl diethyl ammonium halide with 8 halogenated alkanes. The structures of the synthesized products were characterized by Fourier-transform infrared spectroscopy and nuclear magnetic resonance spectroscopy and mass spectrometry. The antifungal activities of these derivatives were tested against 11 plant pathogens, and the preliminary structure-activity relationship is discussed. Some derivatives exhibited moderate to significant antifungal activity due to the fusion of the hydronopyl, a long-chain alkyl, bromine, and iodine anionic groups. In contrast to the structure-activity relationship of compounds 2a, 2b, and 2c, iodine ions in 2f, 2g, and 2f had a significant effect on enhancing the antifungal activity against. Colletotrichum gloeosporioides, Sclerotinia sclrotiorum, Phytophthora capsici, Phomopsis, Sphaeropsis sapinea, Glomerella cingulata, and Fusicodum aesculi. A higher molecular weight could increase the antifungal activity against Fusarium pmqeratuns, Alternaria kikucbiana, Sderotinia sdemtthruns, P. capsici, Phomopth, and S. sapinea. Compounds 2d and 2e exhibited broadspectrum antifungal activity against the tested strains. These derivatives are expected to be used as precursor molecules for novel pesticide development in further research.

服务人员 尚玮姣

服务院士 宋湛谦

PDF文件 浏览全文