beta-Pinene Derived Products With Enhanced In Vitro Antimicrobial Activity

编号 020028301

推送时间 20210322

研究领域 林产化工 

年份 2021 

类型 期刊 

语种 英语

标题 beta-Pinene Derived Products With Enhanced In Vitro Antimicrobial Activity

来源期刊 Natural Product Communications

期 第283期

发表时间 20210208

关键词 β-pinene;  hydronopyl;  antifungal activity;  phytopathogenic fungi;  bacteria; 

摘要 The development of new antimicrobials has always been a research hotspot. In this study, β-pinene-based derivatives were synthesized, and their antimicrobial activity was evaluated. The purpose was to develop some novel, promising new fungicides. Three β-pinene derivatives containing bis-hydronopyl were prepared, and their antifungal and antibacterial activities were evaluated against 6 plant pathogenic fungi and 4 bacterial species; a preliminary structure-activity relationship is discussed. The results indicated that the derivatives containing the blend of alkyl group and bis-hydronopyl had potent inhibitory activities against plant fungal pathogens and bacteria. Among these molecules, bis-hydronopyl dimethyl ammonium bromide showed excellent effects on Colletotrichum acutatum with a half-maximal effective concentration of 0.538 μg/mL, which was lower than that of carbendazim. Scanning electron microscope showed that after administration of bis-hydronopyl dimethyl ammonium bromide (compound 3a), the C. acutatum mycelia were sunken and deformed in comparison with the control group. Furthermore, the inhibitory activities of the methyl derivatives against the plant pathogens were better than those of the ethyl derivatives. These results provide new insights into the inhibition of fungi and bacteria by β-pinene derivatives, which may lead them to be used as precursor molecules for novel pesticides and antimicrobials in further research.

服务人员 尚玮姣

服务院士 宋湛谦

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