Stimuli-Responsive Nanocomposite Hydrogels for Biomedical Applications

编号 020026802

推送时间 20201207

研究领域 林产化工 

年份 2020 

类型 期刊 

语种 英语

标题 Stimuli-Responsive Nanocomposite Hydrogels for Biomedical Applications

来源期刊 ADVANCED FUNCTIONAL MATERIALS

期 第268期

发表时间 20201021

关键词 biomaterials;  nanoparticle-hydrogel hybrids;  self-regulated materials;  stimuli-responsive materials;  tissue engineering; 

摘要 The complex tissue-specific physiology that is orchestrated from the nano- to the macroscale, in conjugation with the dynamic biophysical/biochemical stimuli underlying biological processes, has inspired the design of sophisticated hydrogels and nanoparticle systems exhibiting stimuli-responsive features. Recently, hydrogels and nanoparticles have been combined in advanced nanocomposite hybrid platforms expanding their range of biomedical applications. The ease and flexibility of attaining modular nanocomposite hydrogel constructs by selecting different classes of nanomaterials/hydrogels, or tuning nanoparticle-hydrogel physicochemical interactions widely expands the range of attainable properties to levels beyond those of traditional platforms. This review showcases the intrinsic ability of hybrid constructs to react to external or internal/physiological stimuli in the scope of developing sophisticated and intelligent systems with application-oriented features. Moreover, nanoparticle-hydrogel platforms are overviewed in the context of encoding stimuli-responsive cascades that recapitulate signaling interplays present in native biosystems. Collectively, recent breakthroughs in the design of stimuli-responsive nanocomposite hydrogels improve their potential for operating as advanced systems in different biomedical applications that benefit from tailored single or multi-responsiveness.

服务人员 尚玮姣

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