Synthesis and Antimicrobial and Antifungal Activity of Resin Acid Acetylene Derivatives

编号 020027503

推送时间 20210125

研究领域 林产化工 

年份 2021 

类型 期刊 

语种 英语

标题 Synthesis and Antimicrobial and Antifungal Activity of Resin Acid Acetylene Derivatives

来源期刊 RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

期 第275期

发表时间 20191101

关键词 diterpenoids;  abietic acid;  dehydroabietic acid;  7-formylabietic acid;  maleopimaric acid;  dihydroquinopimaric acid;  antibacterial activity;  fungicidal activity; 

摘要 A series of diterpenes that contain the morpholine, pyrrolidine, benzyl, nitrophenyl, and 1,2,3-tetrazole heterocyclic fragments have been synthesized from acetylene derivatives of abietic, 7-formylabietic, dehydroabietic, maleopimaric, and dihydroquinopimaric acids. The antibacterial activity of the synthesized compounds against microorganisms and pathogenic fungi has been studied, and the primary assessment of their cytotoxicity and hemolytic activity has have been carried out. It has been found that the acetylene derivatives of abietic and dehydroabietic acids that contain the pyrrolidine substituent can effectively inhibit the growth of fungi Candida albicans and Cryptococcus neoformans, and their low hemolytic ability has been shown.

服务人员 尚玮姣

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