Multifunctional novel rosin derivatives based on dehydroabietylamine with metal ion sensing and DNA/BSA binding activities

编号 020032705

推送时间 20220124

研究领域 林产化工 

年份 2022 

类型 期刊 

语种 英语

标题 Multifunctional novel rosin derivatives based on dehydroabietylamine with metal ion sensing and DNA/BSA binding activities

来源期刊 Journal of Molecular Liquids

期 第327期

发表时间 20211208

关键词 Rosin derivative;  DNA binding;  BSA interaction;  Metal ion recognition; 

摘要 Three novel rosin derivatives based on dehydroabietylamine which is an important modified product of rosin,?pyridine?and substituted phenol were synthesized and fully characterized. The DNA binding study results obtained by using?fluorescence spectroscopy, thermal?denaturation, viscosity and circular dichroism (CD) spectroscopy, reveal that they could interact with calf thymus DNA (CT DNA) through?intercalation. The interactions of the title compounds with bovine serum albumins (BSA) were investigated through various spectroscopic techniques. The obtained experimental data show that they could quench the intrinsic fluorophore of BSA by a static quenching mechanism and induce structural alteration in BSA. The?molecular docking?technique was used to ascertain their interactions toward DNA and BSA. Furthermore, they could selectively and irreversibly recognize some individual?metal ions?very well, even to the extent of naked eye recognition. DNA/BSA binding, molecular docking and metal ion recognition findings together prove that the substituent on the phenol group had a great influence on their functions. This work provides a reference for the rational investigation of novel bioactive derivatives of rosin.

服务人员 尚玮姣

服务院士 宋湛谦

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