Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks

编号 040026001

推送时间 20201012

研究领域 森林培育 

年份 2020 

类型 期刊 

语种 英语

标题 Mass Spectrometry Untangles Plant Membrane Protein Signaling Networks

来源期刊 Trends in Plant Science

期 第260期

发表时间 20200901

关键词 kinase;  tandem MOAC;  protein phosphorylation; 
phosphoproteome;  receptor; 

摘要 Plasma membranes (PMs) act as primary cellular checkpoints for sensing signals and controlling solute transport. Membrane proteins communicate with intracellular processes through protein interaction networks. Deciphering these signaling networks provides crucial information for elucidating in vivo cellular regulation. Large-scale proteomics enables system-wide characterization of the membrane proteome, identification of ligand–receptor pairs, and elucidation of signals originating at membranes. In this review we assess recent progress in the development of mass spectrometry (MS)-based proteomic pipelines for determining membrane signaling pathways. We focus in particular on current techniques for the analysis of membrane protein phosphorylation and interaction, and how these proteins may be connected to downstream changes in gene expression, metabolism, and physiology.

服务人员 孙小满

PDF文件 浏览全文