Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications

编号 020027002

推送时间 20201221

研究领域 林产化工 

年份 2020 

类型 期刊 

语种 英语

标题 Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications

来源期刊 Accounts of Chemical Research

期 第270期

发表时间 20190124

关键词 Dynamic Covalent Chemistry;  delivery; 

摘要 Delivery remains a major obstacle restricting the potential action of small molecular drugs as well as novel biologics which cannot readily enter cells without the help of a vector. A successful active delivery process involves three steps: (a) tagging the drug with a vector, (b) effective trafficking of this [drug–vector] conjugate through biological barriers, and finally (c) controlled drug release. While covalent bond formation and/or supramolecular association is involved in the making of the [drug–vector] conjugate, the final step requires precisely a controlled dissociation in order to trigger drug release. Therefore, in pursuit of smart, effective, and nontoxic delivery systems, it has become widely recognized that control over dynamic self-assembly could unleash the efficacy of artificial vectors.

服务人员 尚玮姣

PDF文件 浏览全文