Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

编号 020026203

推送时间 20201026

研究领域 林产化工 

年份 2020 

类型 期刊 

语种 英语

标题 Dynamic covalent hydrogels as biomaterials to mimic the viscoelasticity of soft tissues

来源期刊 Progress in Materials Science

期 第262期

发表时间 20200920

关键词 Biomaterials;  Hydrogel;  Viscoelasticity;  Dynamic covalent chemistry;  Covalent adaptable networks;  Mechanotransduction; 

摘要 The extracellular matrix (ECM) and its mechanical properties play an important role in regulating the cellular responses that occur during tissue regeneration, wound healing, and disease progression. A growing body of research, especially in the fields of mechanobiology and matrix biology, has been devoted to elucidating how the ECM mechanical environment, both in vitro and in vivo, influences cell fate and function. Synthetic materials that faithfully recapitulate key mechanical properties of native tissues provide an important means to understand the mechanisms by which cells sense and remodel their surrounding mechanical environments. However, tissue mechanics is inherently complex, exhibiting dependencies on many timescales. This review highlights recent progress in synthetic biomaterials, particularly polymer networks that capture critical aspects of the dynamic mechanical properties of soft tissues by exploiting dynamic covalent chemistries. Finally, future directions and opportunities in the development and application of viscoelastic biomaterials are discussed.

服务人员 尚玮姣

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