ERF Gene Clusters: Working Together to Regulate Metabolism

编号 040027305

推送时间 20210111

研究领域 森林培育 

年份 2021 

类型 期刊 

语种 英语

标题 ERF Gene Clusters: Working Together to Regulate Metabolism

来源期刊 Trends in Plant Science

期 第273期

发表时间 20200809

关键词 ERF;  transcription factorgene;  clusterjasmonates;  specialized metabolism; 

摘要 Plants produce structurally diverse specialized metabolites, including bioactive alkaloids and terpenoids, in response to biotic and abiotic environmental stresses. The APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) family of transcription factors (TFs) play key roles in regulating biosynthesis of specialized metabolites. Increasing genomic and functional evidence shows that a subset of the ERF genes occurs in clusters on the chromosomes. These jasmonate-responsive ERF TF gene clusters control the biosynthesis of many important metabolites, from natural products, such as nicotine and steroidal glycoalkaloids (SGAs), to pharmaceuticals, such as artemisinin, vinblastine, and vincristine. Here, we review the function, regulation, and evolution of ERF clusters and highlight recent advances in understanding the distinct roles of clustered ERF genes and their possible application in metabolic engineering.

服务人员 孙小满

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