Injectable chitosan hydrogels tailored with antibacterial and antioxidant dual functions for regenerative wound healing

编号 020037801

推送时间 20230116

研究领域 林产化工 

年份 2022 

类型 期刊 

语种 英语

标题 Injectable chitosan hydrogels tailored with antibacterial and antioxidant dual functions for regenerative wound healing

来源期刊 Carbohydrate Polymers

期 第378期

发表时间 20221215

关键词 Chitosan;  Injectable hydrogel;  Antibacterial;  Antioxidant;  Wound dressing; 

摘要 Herein, an injectable self-healing hydrogel with inherent antibacterial activity was fabricated based on the dy-namic covalent bond formation between boronic acid and catechol groups in quaternized chitosan as building blocks in conjunct with the in-situ encapsulation of epigallocatechin-3-gallate (EGCG, a green tea derivative). Benefiting from the catechol groups and therapeutic effect of EGCG, the resulting natural-based injectable hydrogels showed excellent antibacterial and antioxidant dual functions in preventing bacterial infection and scavenging radicals. The hydrogels loaded with EGCG also exhibited good biocompatibility along with contact -active antibacterial activity via a "capture and kill" strategy. The dynamic covalent bonding enables shear -thinning delivery of the gels via syringe, followed by rapid self-healing. Additionally, the in vivo wound heal-ing evaluation in a full-thickness skin defect model revealed the appreciable and regenerative wound healing performance of the hydrogels, demonstrating their great potential as novel wound dressings for wound management.

服务人员 尚玮姣

服务院士 宋湛谦

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