CUL3 E3 ligases in plant development and environmental response

编号 040027804

推送时间 20210215

研究领域 森林培育 

年份 2021 

类型 期刊 

语种 英语

标题 CUL3 E3 ligases in plant development and environmental response

来源期刊 Nature Plants

期 第278期

发表时间 20210115

关键词 plant development;  CUL3 E3 ligases;  BTB/POZ gene;  CRL3; 

摘要 Thirty years of research have revealed the fundamental role of the ubiquitin–proteasome system in diverse aspects of cellular regulation in eukaryotes. The ubiquitin–protein ligases or E3s are central to the ubiquitin–proteasome system since they determine the specificity of ubiquitylation. The cullin–RING ligases (CRLs) constitute one large class of E3s that can be subdivided based on the cullin isoform and the substrate adapter. SCF complexes, composed of CUL1 and the SKP1/F-box protein substrate adapter, are perhaps the best characterized in plants. More recently, accumulating evidence has demonstrated the essential roles of CRL3 E3s, consisting of a CUL3 protein and a BTB/POZ substrate adaptor. In this Review, we describe the variety of CRL3s functioning in plants and the wide range of processes that they regulate. Furthermore, we illustrate how different classes of E3s may cooperate to regulate specific pathways or processes.

服务人员 孙小满

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